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1.  Study Posting (180) Trial #81052, Amyotrophic Lateral Sclerosis (ALS), New York, NY
...powerhouses of the cell, are affected in Lou Gehrig’s disease. Other data suggest that “free radicals”, very reactive oxygen species, contribute to the nerve cell damage. Coenzyme Q10 (CoQ10), a natural ...
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2.  Study Posting (180) Trial #90595, Amyotrophic Lateral Sclerosis (ALS), New York, NY
...allowed to take riluzole, but not other investigational agents during the trial. Scientific Background: Excess free radicals, energy mishandling, excitotoxicity, activation of cell death pathways and inflammation likely all contribute to neurodegeneration ...
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3.  Study Posting (180) Trial #90310, Amyotrophic Lateral Sclerosis (ALS), New York, NY
...allowed to take riluzole, but not other investigational agents during the trial. Scientific Background: Excess free radicals, energy mishandling, excitotoxicity, activation of cell death pathways and inflammation likely all contribute to neurodegeneration ...
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4.  CenterWatch Clinical Industry Provider Profile(1785), Worldwide Clinical Trials, King of Prussia, PA
...esprim (european study of prevention of infarct with molsidomine) • emip-fr (european myocardial infarction project - free radicals) • frax.i.s (fraxiparine in ischemic syndrome) • hero-2 (hirulog in early reperfusion/occlusion 2 ...
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5.  CenterWatch: New Medical Therapies in Disease Category (3), Acute and Chronic Dental Pain
...3, 2004 Metaphore Pharmaceuticals reported positive results from a phase II trial investigating M40403 , a free-radical fighting enzyme mimetic for the treatment of pain. Results demonstrated M40403 improved the efficacy of ...
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6.  Newly Approved Drug Therapies (580) Ellence, Pharmacia & Upjohn,
...with replication and transcription. Epirubicin is also involved in oxidation/reduction reactions by generating cytotoxic free radicals. The antiproliferative and cytotoxic activity of epirubicin is thought to result from these or other ...
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7.  Newly Approved Drug Therapies (621) Nitrostat (nitroglycerin) Tablets, Parke-Davis,
...Fainting or severe weakness • Headache (severe or prolonged) • Skin rash Mechanism of Action Nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3'5 ...
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8.  Newly Approved Drug Therapies (762) Zevalin (ibritumomab tiuxetan), Biogen IDEC,
...the antibody. The beta emission from Y-90 induces cellular damage by the formation of free radicals in the target and neighboring cells. (from Zevalin Prescribing Information) Additional Information Schering AG has ...
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9.  Newly Approved Drug Therapies (873) Tindamax, tinidazole, Presutti Laboratories,
...extracts from Trichomonas have been shown to reduce the molecule's nitro group, producing cytotoxic free radicals. The mechanism of action against Giardia and Entamoeba species is unknown, but activity has been ...
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10.  CenterWatch: New Medical Therapies in Disease Category (565), Post-Surgical Pain
...3, 2004 Metaphore Pharmaceuticals reported positive results from a phase II trial investigating M40403 , a free-radical fighting enzyme mimetic for the treatment of pain. Results demonstrated M40403 improved the efficacy of ...
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