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1.  Newly Approved Drug Therapies (1064) Fusilev (levoleucovorin), Spectrum Pharmaceuticals,
...therapy in osteosarcoma and to reduce the toxicity of methotrexate General Information Fusilev is a folate analog injection. Fusilev protects against the toxic effects of methotrexate, which is a type of chemotherapy that prevents folates from being metabolized to the reduced active form , therefore leading to cell death. Specifically, methotrexate ...
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2.  Newly Approved Drug Therapies (1057) Folotyn (pralatrexate injection), Allos Therapeutics,
...contains pralatrexate, a small molecule chemotherapeutic agent that inhibits dihdrofolate reductase (DHFR). DHFR is a folate dependent enzyme involved in the building of DNA and other processes. Folotyn is transported into tumor cells via the reduced folate carrier (RFC-1). This injectable, small molecule, cytotoxic agent has been designed for improved transport ...
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3. Clinical Trial Results by Drug Names
...rituximab) (including placebo) and three different corticosteroid regimens (including placebo), along with methotrexate (MTX), and folate. Approximately 40 RF-positive patients were enrolled into each of the nine possible combinations. In ...
...and 3 different corticosteroid regimens (including placebo), together with a weekly regimen of MTX and folate. The primary endpoint (ACR20 response) was determined at week 24. After week 24, all patients ...
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4.  Study Posting (5184) Trial #156459, Kidney Disease, Chicago, IL
...from any other value. • Serum transferrin saturation>20% and serum ferritin>100 ng/ml. • Serum folate and vitamin B12>lower limit of normal (LL N). • Median and final pretreatment (i.e ...
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5.  CenterWatch Clinical Industry Provider Profile(4157), SpectraCell Laboratories, Houston, TX
...Thiamin) • Vitamin B2 (Riboflavin) • Vitamin B3 (Niacin) • Vitamin B5 (Pantothenate) • Vitamin B6 • Vitamin B12 • Biotin • Folate • Calcium • Magnesium • Selenium • Zinc • Coenzyme Q • Cysteine • Glutathione • Asparagine • Carnitine • Glutamine • Serine • Lipoic Acid • Oleic ...
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6.  Study Posting (2492) Trial #151242, Alzheimer's Disease, Lafayette, CA
...2 years • Subjects who have experienced a heart attack within the past year • B12 or Folate Deficiency • Chronic Hepatic Disease • History of seizure within the past year • History of stroke Linh ...
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7. Clinical Trial Results by Drug Names
...MTX (10-25 mg/week po or parenterally) together with a corticosteroid regimen, and weekly folate. The primary endpoint (ACR20 response) was determined at week 24; after the week 24 visit ...
...days 8-14, returning to baseline dose by day 16. In addition, all patients received folate (5 mg/week) given as either a single dose or as divided daily doses and ...
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8.  CenterWatch: New Medical Therapies in Disease Category (390), Metastatic Cancer
...on a laboratory measures. Specifically, administration of CoFactor produced an increase producing increases in RBC folate pool expansion (form a mean baseline score of 533 ng/ml to a score of 1295 ng/ml following weekly dosing), urinary folate excretion (an indication of formaldehyde toxicity) showed a small decrease (from a baseline historical baseline ...
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9.  CenterWatch: New Medical Therapies in Disease Category (34), Lung Cancer
...on a laboratory measures. Specifically, administration of CoFactor produced an increase producing increases in RBC folate pool expansion (form a mean baseline score of 533 ng/ml to a score of 1295 ng/ml following weekly dosing), urinary folate excretion (an indication of formaldehyde toxicity) showed a small decrease (from a baseline historical baseline ...
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10.  CenterWatch: New Medical Therapies in Disease Category (402), Cancer/Tumors
...on a laboratory measures. Specifically, administration of CoFactor produced an increase producing increases in RBC folate pool expansion (form a mean baseline score of 533 ng/ml to a score of 1295 ng/ml following weekly dosing), urinary folate excretion (an indication of formaldehyde toxicity) showed a small decrease (from a baseline historical baseline ...
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11.  CenterWatch: New Medical Therapies in Disease Category (426), Colorectal Cancer
...on a laboratory measures. Specifically, administration of CoFactor produced an increase producing increases in RBC folate pool expansion (form a mean baseline score of 533 ng/ml to a score of 1295 ng/ml following weekly dosing), urinary folate excretion (an indication of formaldehyde toxicity) showed a small decrease (from a baseline historical baseline ...
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12.  CenterWatch: New Medical Therapies in Disease Category (37), Skin Cancer
...on a laboratory measures. Specifically, administration of CoFactor produced an increase producing increases in RBC folate pool expansion (form a mean baseline score of 533 ng/ml to a score of 1295 ng/ml following weekly dosing), urinary folate excretion (an indication of formaldehyde toxicity) showed a small decrease (from a baseline historical baseline ...
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13.  Newly Approved Drug Therapies (849) Alimta (pemetrexed for injection), Eli Lilly,
...Mechanism of Action Pemetrexed is an antifolate antineoplastic agent that exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. In cancer subjects, folic acid can stimulate tumor ...
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