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1. Study Posting (783) Trial #153214, Epilepsy, Lexington, KY ...one and up to two anti-epileptic drugs. Exclusion Criteria • Current use of oxcarbazepine or phenytoin anti-epileptic medications. • Use of felbamate within the last 12 months. • History of generalized status ...View Page
2. Newly Approved Drug Therapies (959) Selzentry (maraviroc), Pfizer, ...plus CYP3A inducers (without a strong CYP3A inhibitor) These include: • efavirenz • rifampin • carbamazepine, phenobarbital, and phenytoin The recommended initial dose of Selzentry is 600 mg twice daily. Clinical Results FDA Approval ...View Page
3. Study Posting (77) Trial #137471, Prostate Cancer, Bronx, NY ...use of systemic corticosteroids or anticonvulsants that may affect bone loss such as carbamazepine, phenobarbital, phenytoin, valproic acid or primidone • Consume more than 14 alcoholic beverages per week or history of ...View Page
4. Study Posting (5011) Trial #128578, Metastatic Cancer, Various Cities, Russian Federation ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
5. Study Posting (5011) Trial #128555, Metastatic Cancer, Various Cities, Poland ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
6. Study Posting (5011) Trial #128551, Metastatic Cancer, Various Cities, Italy ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
7. Study Posting (5011) Trial #128553, Metastatic Cancer, Various Cities, Germany ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
8. Study Posting (1918) Trial #158907, Lung Cancer, Savannah, GA ...prior and no concurrent CYP3A4 inducers, including any of the following: • Rifampin • Rifabutin • Carbamazepine • Phenobarbital • Phenytoin • Hypericum perforatum (St. John's wort) • Efavirenz • Tipranavir • No concurrent agents with proarrhythmic potential, including ...View Page
9. Study Posting (1918) Trial #159848, Lung Cancer, Savannah, GA ...prior and no concurrent CYP3A4 inducers, including any of the following: • Rifampin • Rifabutin • Carbamazepine • Phenobarbital • Phenytoin • Hypericum perforatum (St. John's wort) • Efavirenz • Tipranavir • No concurrent therapeutic doses of coumarin-derivative ...View Page
10. Study Posting (1918) Trial #159917, Kidney Cancer, Savannah, GA ...and no concurrent treatment with any of the following*: • Cytochrome P450 enzyme-inducing antiepileptic drugs (phenytoin, carbamazepine, or phenobarbital) • Hypericum perforatum (St. John's wort) • Ketoconazole • Dexamethasone • Dysrhythmic drugs (i.e ...View Page
11. Study Posting (1918) Trial #158890, Endometrial Cancer, Savannah, GA ...treatment that would contraindicate study therapy • No concurrent enzyme-inducing antiepileptic drugs (EIAEDs) (e.g., phenytoin, carbamazepine, or phenobarbital) or any other CYP3A4 inducer (e.g., rifampin or St. John's ...View Page
12. Study Posting (5011) Trial #128577, Breast Cancer, Various Cities, Russian Federation ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
13. Study Posting (5011) Trial #128554, Breast Cancer, Various Cities, Poland ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
14. Study Posting (5011) Trial #128550, Breast Cancer, Various Cities, Italy ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
15. Study Posting (5011) Trial #128552, Breast Cancer, Various Cities, Germany ...peripheral neuropathy =Grade 2. • Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
16. Study Posting (4949) Trial #127578, Breast Cancer, Glendale, WI ...of the study results. Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
17. Study Posting (4949) Trial #127568, Breast Cancer, Washington, DC ...of the study results. Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
18. Study Posting (4949) Trial #127563, Breast Cancer, Washington, DC ...of the study results. Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
19. Study Posting (4949) Trial #144018, Breast Cancer, Kirkland, WA ...of the study results. Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
20. Study Posting (4949) Trial #121398, Breast Cancer, Memphis, TN ...of the study results. Use of cytochrome P450 enzyme-inducing anti-epileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) is not allowed. • Cardiac disease: • Congestive heart failure >class II New York ...View Page
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