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1.  CenterWatch: New Medical Therapies in Disease Category (164), Depression
...eight adult subjects who received asenapine 5 mg twice daily, asenapine 10 mg twice daily, haloperidol 4 mg twice daily or placebo, for six weeks. The primary endpoint was the change ...
...two. The PANSS score was significantly better for the asenapine 5 mg, 10 mg and haloperidol arms versus placebo (-21.3, - 19.4, -20.0 and -14.6, respectively). Statistical significance ...
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2.  CenterWatch: New Medical Therapies in Disease Category (276), Benign Prostatic Hyperplasia (Enlarged Prostate)
...dose risperidone; low-dose risperidone plus placebo; high-dose risperidone plus placebo; ACP-103 plus haloperidol; or haloperidol plus placebo. The primary endpoint was antipsychotic efficacy as measured after day 42 compared to ...
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3.  CenterWatch: New Medical Therapies in Disease Category (135), Schizophrenia and Schizoaffective Disorders
...eight adult subjects who received asenapine 5 mg twice daily, asenapine 10 mg twice daily, haloperidol 4 mg twice daily or placebo, for six weeks. The primary endpoint was the change ...
...two. The PANSS score was significantly better for the asenapine 5 mg, 10 mg and haloperidol arms versus placebo (-21.3, - 19.4, -20.0 and -14.6, respectively). Statistical significance ...
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4.  CenterWatch: New Medical Therapies in Disease Category (448), Psychosis
...that the drug met its primary endpoint, with a significant reduction in observed symptoms of haloperidol-induced akathisia (motor disturbance), and a significant reduction in the elevated serum prolactin levels (hyperprolactinemia) caused by haloperidol; hyperprolactinemia can cause sexual and menstrual disturbance, increase risk of osteoporosis, and promote mammary tissue ...
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5.  CenterWatch: New Medical Therapies in Disease Category (14), Anxiety Disorders
...that the drug met its primary endpoint, with a significant reduction in observed symptoms of haloperidol-induced akathisia (motor disturbance), and a significant reduction in the elevated serum prolactin levels (hyperprolactinemia) caused by haloperidol; hyperprolactinemia can cause sexual and menstrual disturbance, increase risk of osteoporosis, and promote mammary tissue ...
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6.  Study Posting (1918) Trial #160135, Metastatic Cancer, Savannah, GA
...disopyramide phosphate, amiodarone, sotalol hydrochloride, ibutilide, dofetilide) • Antipsychotic agents (e.g., chlorpromazine, mesoridazine, thioridazine, pimozide, haloperidol, droperidol) • Select antibiotics (e.g., erythromycin, clarithromycin, sparfloxacin, pentamidine) • Narcotic analgesics (e.g., levomethadyl, methadone ...
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7.  Study Posting (1918) Trial #158907, Lung Cancer, Savannah, GA
...concurrent agents with proarrhythmic potential, including any of the following: • Quinidine • Procainamide • Disopyramide • Sotalol • Probucol • Haloperidol • Risperidone • Indapamide • Flecainide • No concurrent therapeutic anticoagulation for thromboembolic disease • Concurrent low-dose coumadin (≤ 2 ...
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8.  Study Posting (1918) Trial #159917, Kidney Cancer, Savannah, GA
...Ketoconazole • Dexamethasone • Dysrhythmic drugs (i.e., terfenadine, quinidine, procainamide, sotalol, probucol, bepridil, indapamide, or flecainide) • Haloperidol • Risperidone • Rifampin • Grapefruit juice or grapefruit NOTE: • *Topical and inhaled steroids are allowed • Concurrent participation ...
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9.  Study Posting (1918) Trial #160134, Breast Cancer, Savannah, GA
...disopyramide phosphate, amiodarone, sotalol hydrochloride, ibutilide, dofetilide) • Antipsychotic agents (e.g., chlorpromazine, mesoridazine, thioridazine, pimozide, haloperidol, droperidol) • Select antibiotics (e.g., erythromycin, clarithromycin, sparfloxacin, pentamidine) • Narcotic analgesics (e.g., levomethadyl, methadone ...
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10.  CenterWatch: New Medical Therapies in Disease Category (20), Bipolar Disorders
...aripiprazole showed significant improvement in their symptoms and significantly higher response rates compared to either haloperidol or placebo. A separate 12-week, multicenter, double-blind study enrolled 347 subjects with acute ...
...significantly greater percentage of subjects responded to treatment with aripiprazole compared to patients treated with haloperidol at Week 12 (49.7% vs. 28.4%). Both studies were presented at the 156th ...
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11.  Newly Approved Drug Therapies (1043) Saphris (asenapine), Schering-Plough,
...Three fixed-dose, short-term (6 week), randomized, double-blind, placebo-controlled, and active-controlled (haloperidol, risperidone, and olanzapine) trials enrolled adult patients who met DSM-IV criteria for schizophrenia and ...
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