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1.  Newly Approved Drug Therapies (1037) Efient (prasugrel), Eli Lilly,
...from sticking or clumping together. Prasugrel blocks a specific receptor on the platelet surface, P2Y12 adenosine diphosphate (ADP), and prevents platelets from clumping, which can result in clogged arteries and may ...
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2.  Study Posting (77) Trial #154753, Vascular Diseases, Bronx, NY
...ischemic attack or stroke • Have a history of seizure disorder • Have a known hypersensitivity to adenosine, dipyridamole or aminophylline • Have known or suspected bronchoconstrictive or bronchospastic lung disease Sanford Abramson, Study ...
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3.  Study Posting (1918) Trial #158880, Coronary Artery Disease, Savannah, GA
...Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2 x Upper Limit of Normal (ULN). • Adenosine, aminophylline, nicotinic acid, pentoxifylline, theophylline, and any cardioplegia solution containing adenosine, dipyridamole, lidoflazine, or lidocaine within 24 hours before surgery: • Dipyridamole within 2 days and allopurinol ...
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4.  Newly Approved Drug Therapies (579) Cafcit Injection, Roxane Laboratories,
...and (8) increased oxygen consumption. Most of these effects have been attributed to antagonism of adenosine receptors, both A1 and A2 subtypes, by caffeine, which has been demonstrated in receptor binding ...
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5.  Newly Approved Drug Therapies (724) Foradil Aerolizer (formoterol fumarate inhalation powder), Novartis,
...part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition ...
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6.  Newly Approved Drug Therapies (934) Brovana (arformoterol tartrate), Sepracor,
...muscle. They cause stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased intracellular cyclic AMP levels cause relaxation of bronchial smooth muscle and ...
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7.  CenterWatch: New Medical Therapies in Disease Category (204), Peripheral Arterial Occlusive Disease
...Therapeutics and Astellas issued positive results of a phase III trial of their selective A2A-adenosine receptor agonist regadenoson , under investigation as a pharmacologic stress agent in cardiovascular imaging procedures. Trial ...
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8.  CenterWatch: New Medical Therapies in Disease Category (213), Heart Disease
...1,231 subjects, all of who received a clinically indicated baseline MPI study using Adenoscan (adenosine injection). Subjects then received either regadenoson or Adenoscan in a second MPI study. The trial ...
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9.  CenterWatch: New Medical Therapies in Disease Category (50), Coronary Artery Disease
...Therapeutics and Astellas issued positive results of a phase III trial of their selective A2A-adenosine receptor agonist regadenoson , under investigation as a pharmacologic stress agent in cardiovascular imaging procedures. Trial ...
...as a pharmacologic stress agent in cardiac perfusion imaging studies. CVT-3146, a selective A2A adenosine receptor agonist, is being co-developed by CV Therapeutics and Fujisawa Healthcare . March 25, 2002 ...
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10.  CenterWatch: New Medical Therapies in Disease Category (385), Blood Clots
...drug clopidogrel, followed by induction of platelet aggregation with one of two dose concentrations of adenosine diphosphate (5 micromolar or 20 micromolar). June 6, 2005 Inspire Pharmaceuticals has issued positive results ...
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11.  Newly Approved Drug Therapies (704) Ventolin HFA (albuterol sulfate inhalation aerosol), GlaxoSmithKline,
...activation of adenylcyclase, and to an increase in the intracellular concentration of cyclic-3',5'-adenosine monophosphate (cyclic AMP). This increase of cyclic AMP leads to the activation of protein kinase ...
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12.  Newly Approved Drug Therapies (730) Viread (tenofovir disoproxil fumarate), Gilead,
...HIV. Its active ingredient, tenofovir disoproxil fumarate, is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. In the body, this analog is converted to tenofovir, then is formed to tenofovir ...
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13.  Newly Approved Drug Therapies (797) Hepsera (adefovir dipivoxil), Gilead,
...Adefovir dipivoxil is a diester prodrug of adefovir, which is an acyclic nucleotide analog of adenosine monophosphate. Adefovir is phosphorylated to the active metabolite, adefovir diphosphate, by cellular kinases. Adefovir diphosphate ...
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14.  Newly Approved Drug Therapies (706) Axert (almotriptan malate) tablets, Pharmacia,
...HT 2, 5-HT 3, 5-HT 4, 5-HT 6; alpha or beta adrenergic; adenosine (A1, A2); angiotensin (AT 1, AT 2); dopamine (D1, D2); endothelin (ET A, ET B ...
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15.  CenterWatch: New Medical Therapies in Disease Category (281), Heart Failure
...1,231 subjects, all of who received a clinically indicated baseline MPI study using Adenoscan (adenosine injection). Subjects then received either regadenoson or Adenoscan in a second MPI study. The trial ...
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